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Article

Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway.

Journal of lipid research - 1 Jan 2017

Alecu Irina, Othman Alaa, Penno Anke, Saied Essa M, Arenz Christoph, von Eckardstein Arnold, Hornemann Thorsten

Abstract excerpt

The 1-deoxysphingolipids (1-deoxySLs) are atypical sphingolipids (SLs) that are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during SL synthesis. The 1-deoxySLs are toxic to neurons and pancreatic β-cells. Pathologically elevated 1-deoxySLs cause the inherited neuropathy, hereditary sensory autonomic neuropathy type 1 (HSAN1), and are also found in T2D. Diabetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27872144
DOI: 10.1194/jlr.M072421
PMCID: PMC5234722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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