Article

1-Deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway

2025-05-13

Abstract excerpt

1-Deoxysphingolipids are non-canonical sphingolipids linked to several diseases, but their cellular effects are poorly understood. Here, we utilize lipid chemical biology approaches to investigate the role of 1-deoxysphingolipid metabolism on the properties and functions of secretory membranes. We first applied organelle-specific bioorthogonal labeling to visualize the subcellular distribution of metabolically tag...

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Literature Corpus work: 8bef52ab-81c7-5362-8949-d52966563347
DOI: 10.1101/2025.05.13.652513

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