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Article

Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay.

Nature chemical biology - 1 Feb 2015

Kamat Siddhesh S, Camara Kaddy, Parsons William H, Chen Dong-Hui, Dix Melissa M, Bird Thomas D, Howell Amy R, Cravatt Benjamin F

Abstract excerpt

Lysophosphatidylserines (lyso-PSs) are a class of signaling lipids that regulate immunological and neurological processes. The metabolism of lyso-PSs remains poorly understood in vivo. Recently, we determined that ABHD12 is a major brain lyso-PS lipase, implicating lyso-PSs in the neurological disease polyneuropathy, hearing loss, ataxia, retinitis pigmentosa and cataract (PHARC), which is caused by null...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25580854
DOI: 10.1038/nchembio.1721
PMCID: PMC4301979

Genes

ABHD12

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Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay.PMID 25580854Read ↗

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