Article

SPNS1 is required for the transport of lysosphingolipids and lysoglycerophospholipids from lysosomes

2022-12-14

Abstract excerpt

Accumulation of sphingolipids, especially sphingosines, in the lysosomes is attributed to the pathogenesis of several lysosomal storage diseases. In search for a lysosomal protein that mediates the release of sphingosines, we identified SPNS1 which shares the highest homology to SPNS2, a sphingosine-1-phosphate (S1P) transporter. We generated knockout cells and mice for Spns1 and employed lipidomics and metabolom...

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Literature Corpus work: 1df1740e-d7c1-514e-819c-d4f19791c781
DOI: 10.1101/2022.12.14.520377

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