Article

Single-cell copy number lineage tracing enabling gene discovery

2020-04-13

Abstract excerpt

Aneuploidy plays critical roles in genome evolution. Alleles, whose dosages affect the fitness of an ancestor, will have altered frequencies in the descendant populations upon perturbation. Single-cell sequencing enables comprehensive genome-wide copy number profiling of thousands of cells at various evolutionary stage and lineage. That makes it possible to discover dosage effects invisible at tissue level, provid...

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Literature Corpus work: f1f9f56e-fe10-5c25-bea7-af432997f7d6
DOI: 10.1101/2020.04.12.038281

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