Article
Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis.
Nature communications - 12 Jan 2021
Gao Teng, Ptashkin Ryan, Bolton Kelly L, Sirenko Maria, Fong Christopher, Spitzer Barbara, Menghrajani Kamal, Ossa Juan E Arango, Zhou Yangyu, Bernard Elsa, Levine Max, Martinez Juan S Medina, Zhang Yanming, Franch-Expósito Sebastià, Patel Minal, Braunstein Lior Z, Kelly Daniel, Yabe Mariko, Benayed Ryma, Caltabellotta Nicole M, Philip John, Paraiso Ederlinda, Mantha Simon, Solit David B, Diaz Luis A, Berger Michael F, Klimek Virginia, Levine Ross L, Zehir Ahmet, Devlin Sean M, Papaemmanuil Elli
Abstract excerpt
Stably acquired mutations in hematopoietic cells represent substrates of selection that may lead to clonal hematopoiesis (CH), a common state in cancer patients that is associated with a heightened risk of leukemia development. Owing to technical and sample size limitations, most CH studies have characterized gene mutations or mosaic chromosomal alterations (mCAs) individually. Here we leverage peripheral blood...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.