Article
Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jan 2021
Giovinazzo Daniel, Bursac Biljana, Sbodio Juan I, Nalluru Sumedha, Vignane Thibaut, Snowman Adele M, Albacarys Lauren M, Sedlak Thomas W, Torregrossa Roberta, Whiteman Matthew, Filipovic Milos R, Snyder Solomon H, Paul Bindu D
Abstract excerpt
Alzheimer's disease (AD), the most common cause of dementia and neurodegeneration in the elderly, is characterized by deterioration of memory and executive and motor functions. Neuropathologic hallmarks of AD include neurofibrillary tangles (NFTs), paired helical filaments, and amyloid plaques. Mutations in the microtubule-associated protein Tau, a major component of the NFTs, cause its hyperphosphorylation in...
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