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Hydrogen sulfide (H <sub>2</sub> S) coordinates redox balance, carbon metabolism, and mitochondrial bioenergetics to suppress SARS-CoV-2 infection

2024-12-30

Abstract excerpt

Viruses exploit host metabolism for replication and immune-regulation. Understanding how SARS-CoV-2 alters the host metabolism may lead to treatments for COVID-19. We report that a ubiquitous gaseous molecule, hydrogen sulfide (H 2 S), regulates redox, metabolism, and mitochondrial bioenergetics to control SARS-CoV-2. Virus replication is associated with down-regulation of the H 2 S-producing enzymes cystathioni...

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Identifiers and source

Literature Corpus work
c6d4c379-f897-56dc-b737-19c8074af375
DOI
10.1101/2024.12.29.630646
Open publication

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