Article
Mutant superoxide dismutase 1-catalyzed hydrogen therapy for amyotrophic lateral sclerosis achieved by intercepting oxidative stress-neuroinflammation crosstalk.
Acta biomaterialia - 1 Aug 2026
Sun Yihui, Wang Yingshuai, He Qianbo, Zhao Min, Guo Jiaru, Xu Chunjie, Yan Qiupeng, Chen Yanchun, Zhang Bingqiang, Du Hongmei, Huo Jing, Zhang Yong, Zhang Haoyun, Guan Yingjun, He Qianjun
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron degeneration in the brain and spinal cord, with mutant superoxide dismutase 1 (SOD1) induced oxidative stress and neuroinflammation as key pathogenic drivers. Here, we uncover that mutant SOD1 is both a Fenton-like agent able for catalytical generation of ·OH and a hydrogenation catalyst for H2...
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