Article

Sodium Thiosulfate acts as an H <sub>2</sub> S mimetic to prevent intimal hyperplasia via inhibition of tubulin polymerization

2021-09-12

Abstract excerpt

<h4>Background</h4> Intimal hyperplasia (IH) remains a major limitation in the long-term success of any type of revascularization. IH is due to vascular smooth muscle cell (VSMC) dedifferentiation, proliferation and migration. The gasotransmitter Hydrogen Sulfide (H 2 S) inhibits IH in pre-clinical models. However, there is currently no clinically approved H 2 S donor. Here we used sodium thiosulfate (STS), a c...

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Literature Corpus work: 4eb34d0a-4268-52b5-823b-dd19cb173c55
DOI: 10.1101/2021.09.09.459573

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