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Article

Mechanism-based inhibition of human persulfide dioxygenase by γ-glutamyl-homocysteinyl-glycine.

The Journal of biological chemistry - 10 Aug 2018

Kabil Omer, Motl Nicole, Strack Martin, Seravalli Javier, Metzler-Nolte Nils, Banerjee Ruma

Abstract excerpt

Hydrogen sulfide (H2S) is a signaling molecule with many beneficial effects. However, its cellular concentration is strictly regulated to avoid toxicity. Persulfide dioxygenase (PDO or ETHE1) is a mononuclear non-heme iron-containing protein in the sulfide oxidation pathway catalyzing the conversion of GSH persulfide (GSSH) to sulfite and GSH. PDO mutations result in the autosomal-recessive disorder ethylmalonic...

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Identifiers

PMID: 29980601
DOI: 10.1074/jbc.RA118.004096
PMCID: PMC6093238

Genes

ETHE1

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