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Article

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.

Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 2010

van Eersel Janet, Ke Yazi D, Liu Xin, Delerue Fabien, Kril Jillian J, Götz Jürgen, Ittner Lars M

Abstract excerpt

Alzheimer's disease (AD) brains are characterized by amyloid-beta-containing plaques and hyperphosphorylated tau-containing neurofibrillary tangles (NFTs); however, in frontotemporal dementia, the tau pathology manifests in the absence of overt amyloid-beta plaques. Therapeutic strategies so far have primarily been targeting amyloid-beta, although those targeting tau are only slowly beginning to emerge. Here, we...

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Identifiers

PMID: 20643941
DOI: 10.1073/pnas.1009038107
PMCID: PMC2922247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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