Article

Protein thiol alterations drive aberrant phase separation in aging

2023-11-08

Abstract excerpt

Cellular homeostasis relies on precise regulation through chemical processes, such as protein posttranslational modifications (PTM) and physical processes, such as biomolecular condensation. Aging disrupts this balance, increasing susceptibility to diseases and death. However, the mechanisms behind age-related pathogenesis remain elusive. In this study, we dissected various cysteine PTMs and their impact on protei...

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Literature Corpus work: 6613682a-f1e6-5b9e-999b-1673737c1837
DOI: 10.1101/2023.11.07.566021

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