Article
Nuclear IL-33 restrains the early conversion of fibroblasts to an extracellular matrix-secreting phenotype.
Scientific reports - 8 Jan 2021
Gatti Francesca, Mia Sobuj, Hammarström Clara, Frerker Nadine, Fosby Bjarte, Wang Junbai, Pietka Wojciech, Sundnes Olav, Hol Johanna, Kasprzycka Monika, Haraldsen Guttorm
Abstract excerpt
Interleukin (IL)-33 is a cytokine that appears to mediate fibrosis by signaling via its receptor ST2 (IL-33R/IL1RL1). It is also, however, a protein that after synthesis is sorted to the cell nucleus, where it appears to affect chromatin folding. Here we describe a novel role for nuclear IL-33 in regulating the fibroblast phenotype in murine kidney fibrosis driven by unilateral ureteral obstruction....
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