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MKL1 mediates TGF‐β‐induced CTGF transcription to promote renal fibrosis

21 Oct 2019

Abstract excerpt

Aberrant fibrogenesis impairs the architectural and functional homeostasis of the kidneys. It also predicts poor diagnosis in patients with end-stage renal disease (ESRD). Renal tubular epithelial cells (RTEC) can trans-differentiate into myofibroblasts to produce extracellular matrix proteins and contribute to renal fibrosis. Connective tissue growth factor (CTGF) is a cytokine upregulated in RTECs during renal...

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PMID: 31637729
DOI: 10.1002/jcp.29356

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