Article

IL33-regulated NPM1 promotes fibroblast-to-myofibroblast transition via ERK/AP-1 signaling in silica-induced pulmonary fibrosis

2022-10-12

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Silicosis is a global occupational lung disease caused by the accumulation of silica dust. There is a lack of effective clinical drugs, and the pathogenic mechanisms remain obscure. Interleukin 33 (IL33), a pleiotropic cytokine, could promote wound healing and tissue repair via the receptor ST2. However, the mechanisms by which IL33 involves in silicosis prog...

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Literature Corpus work: cfb83eb7-13ac-5d16-a040-310a1ec9bd78
DOI: 10.21203/rs.3.rs-1982434/v2

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