Nuclear IL-33-driven UBE4B expression tilts human macrophages toward the M2 phenotype via p53 ubiquitination.

Abstract excerpt

Interleukin-33 (IL-33), a member of the IL-1 cytokine family, has emerged as a chromatin-associated cytokine with the potential to modulate gene expression through chromatin remodeling and epigenetic regulation. Despite its established role in immune responses, the specific genes regulated by nuclear IL-33 and its mechanisms remain elusive. Our research has found that overexpression of full-length IL-33 in human...

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