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Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis

12 Feb 2020

Abstract excerpt

Acute kidney injury (AKI) and chronic kidney diseases are associated with high mortality and morbidity. Although the underlying mechanisms determining the transition from acute to chronic injury are not completely understood, immune-mediated processes are critical in renal injury. We have performed a comparison of 2 mouse models leading to either kidney regeneration or fibrosis. Using global gene expression...

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PMID: 32051345
DOI: 10.1172/jci.insight.130651

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