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Translational Profiles of Medullary Myofibroblasts during Kidney Fibrosis

21 Mar 2014

Abstract excerpt

Myofibroblasts secrete matrix during chronic injury, and their ablation ameliorates fibrosis. Development of new biomarkers and therapies for CKD will be aided by a detailed analysis of myofibroblast gene expression during the early stages of fibrosis. However, dissociating myofibroblasts from fibrotic kidney is challenging. We therefore adapted translational ribosome affinity purification (TRAP) to isolate and...

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PMID: 24652793
DOI: 10.1681/asn.2013101143

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