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Article

Runt-related transcription factors: from pathogenesis to therapeutic targets in multiple-organ fibrosis

28 Apr 2025

Abstract excerpt

Fibrosis is a partially manageable process that leads to scarring and tissue hardening by prompting myofibroblasts to deposit significant amounts of extracellular matrix (ECM) following injury. It results in detrimental consequences and pathological characteristics, which hinder the functioning of associated organs and increase mortality rates. Runt-related transcription factors ( RUNX ) are part of a highly...

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Identifiers

PMID: 40356603
DOI: 10.3389/fcell.2025.1528645

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