Article

IL-33 regulates gene expression in intestinal epithelial cells independently of its nuclear localization

2018-03-28

Abstract excerpt

IL-33 is a cytokine found in the extracellular space (mature IL-33) or in the cell nucleus (full-length IL-33). Nuclear accumulation of IL-33 has been reported in intestinal epithelial cells (IEC) during intestinal inflammation and cancer, but a functional role for this nuclear form remains unclear. To study the role of nuclear IL-33 in IEC, we generated transgenic mice expressing full-length IL-33 in the intest...

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Literature Corpus work: 2f98e36c-89a2-506b-8e8d-6659e7dc78d2
DOI: 10.1101/291039

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