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Article

Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures.

Neurobiology of disease - 1 Mar 2021

Vavers Edijs, Zvejniece Baiba, Stelfa Gundega, Svalbe Baiba, Vilks Karlis, Kupats Einars, Mezapuke Rudolfs, Lauberte Lasma, Dambrova Maija, Zvejniece Liga

Abstract excerpt

There is a growing body of evidence demonstrating the significant involvement of the sigma-1 chaperone protein in the modulation of seizures. Several sigma-1 receptor (Sig1R) ligands have been demonstrated to regulate the seizure threshold in acute and chronic seizure models. However, the mechanism by which Sig1R modulates the excitatory and inhibitory pathways in the brain has not been elucidated. The aim of...

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PMID: 33385516
DOI: 10.1016/j.nbd.2020.105244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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