Article
Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1).
Investigative ophthalmology & visual science - 29 Sept 2011
Ha Yonju, Saul Alan, Tawfik Amany, Williams Cory, Bollinger Kathryn, Smith Robert, Tachikawa Masanori, Zorrilla Eric, Ganapathy Vadivel, Smith Sylvia B
Abstract excerpt
PURPOSE: Sigma receptor 1 (σR1) is expressed abundantly in the eye, and several reports suggest that this putative molecular chaperone plays a role in lens cell survival, control of intraocular pressure (IOP), and retinal neuroprotection. The present study examined the consequence of the absence of σR1 on ocular development, structure, and function. METHODS: Wild-type (σR1⁺/⁺), heterozygous (σR1⁺/⁻), and...
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