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Article

Behavioural phenotyping of knockout mice for the sigma-1 (σ₁) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations.

Journal of psychopharmacology (Oxford, England) - 1 Jul 2011

Chevallier Nathalie, Keller Emeline, Maurice Tangui

Abstract excerpt

The sigma-1 (σ₁) protein regulates calcium homeostasis and acts as an endoplasmic reticulum chaperone. It can be activated by ligands which impact memory, depression, anxiety or addiction processes. We here characterized the behavioural phenotype of knockout (KO) mice for the σ₁ protein. Two-month old male σ₁⁻/⁻ mice showed signs of anxiety in the open-field, passive avoidance or elevated plus-maze test, but...

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Identifiers

PMID: 21555330
DOI: 10.1177/0269881111400648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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