Article
Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice.
The European journal of neuroscience - 1 Oct 2003
Langa Francina, Codony Xavier, Tovar Victoria, Lavado Alfonso, Giménez Estela, Cozar Patricia, Cantero Marta, Dordal Albert, Hernández Enric, Pérez Raquel, Monroy Xavier, Zamanillo Daniel, Guitart Xavier, Montoliu Lluís
Abstract excerpt
Sigma (sigma) sites are a type of nonopiate receptor whose role has been associated with several behaviours, including anxiety, depression, analgesia, learning processes and psychosis. Although there are several known sigma receptor types, only the type I receptor (sigma 1) has been cloned. To uncover the in vivo relevance of sigma-receptors, we have generated knockout mice for sigma 1. Despite the broad...
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