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Article

Sigma-1 receptor knockout mice display a depressive-like phenotype.

Behavioural brain research - 17 Mar 2009

Sabino Valentina, Cottone Pietro, Parylak Sarah L, Steardo Luca, Zorrilla Eric P

Abstract excerpt

Activation of sigma-1 receptors (Sig-1R) reportedly has antidepressant-like action. Limited data suggest that Sig-1Rs also modulate anxiety-related behaviors. The present experiments measured depressive-like, anxiety-like and motor behavior in Sig-1R knockout mice and their wildtype littermates. Sig-1R knockout mutants showed increased immobility in the forced swimming test, a depressive-like phenotype, but...

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Source

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Identifiers

PMID: 19100292
DOI: 10.1016/j.bbr.2008.11.036
PMCID: PMC2667953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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