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Article

Role of Sigma 1 Receptor in Retinal Degeneration of the Ins2Akita/+ Murine Model of Diabetic Retinopathy.

Investigative ophthalmology & visual science - 1 May 2016

Wang Jing, Cui Xuezhi, Roon Penny, Smith Sylvia B

Abstract excerpt

PURPOSE: Sigma receptor 1 (Sigma1R), a nonopioid putative molecular chaperone, has neuroprotective properties in retina. This study sought to determine whether delaying administration of (+)-pentazocine, a high-affinity Sigma1R ligand after onset of diabetes in Ins2Akita/+ diabetic mice would afford retinal neuroprotection and to determine consequences on retinal phenotype in Ins2Akita/+ diabetic mice in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Tomography, Optical Coherence

Source

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Identifiers

PMID: 27206247
DOI: 10.1167/iovs.15-18995
PMCID: PMC4884059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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