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Article

The involvement of the sigma-1 receptor in neurodegeneration and neurorestoration.

Journal of pharmacological sciences - 1 Jan 2015

Ruscher Karsten, Wieloch Tadeusz

Abstract excerpt

The sigma-1 receptor (Sig-1R) is a single 25 kD polypeptide and a chaperone protein immersed in lipid rafts of the endoplasmic reticulum (ER) where it interacts with mitochondria at the mitochondria-associated ER membrane domain (MAM). Upon activation, the Sig-1R binds to the inositol trisphosphate receptor (IP3R), and modulates cellular calcium (Ca(2+)) homeostasis. Also, the activated Sig-1R modulates plasma...

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Source

Identifiers

PMID: 25704015
DOI: 10.1016/j.jphs.2014.11.011

Genes

SIGMAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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