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Article

Formalin-induced pain is reduced in sigma(1) receptor knockout mice.

European journal of pharmacology - 21 Mar 2005

Cendán Cruz Miguel, Pujalte José Miguel, Portillo-Salido Enrique, Montoliu Lluís, Baeyens José M

Abstract excerpt

The role of sigma1 receptors in non-acute pain has not been explored. In this study we show that both phases of formalin-induced pain were reduced by approximately 55% in sigma1 receptor knockout mice in comparison to wild-type animals. These results suggest that the tonic pain induced by formalin is altered in mice lacking sigma1 receptors, and highlight the potential usefulness of further studies of the role of...

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Identifiers

PMID: 15777781
DOI: 10.1016/j.ejphar.2005.01.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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