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Article

Epistatic, synthetic, and balancing interactions among tubulin missense mutations affecting neurite growth in Caenorhabditis elegans.

Molecular biology of the cell - 15 Feb 2021

Lee Ho Ming Terence, Sayegh Natalie Yvonne, Gayek A Sophia, Jao Susan Laura Javier, Chalfie Martin, Zheng Chaogu

Abstract excerpt

Mutations in tubulins affect microtubule (MT) dynamics and functions during neuronal differentiation and their genetic interaction provides insights into the regulation of MT functions. We previously used Caenorhabditis elegans touch receptor neurons to analyze the cellular impact of tubulin mutations and reported the phenotypes of 67 tubulin missense mutations, categorized into three classes: loss-of-function...

Topics

Alleles
Amino Acid Sequence
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Microtubules
Mutation
Mutation, Missense
Neurites
Neurogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Tubulin

Source

Open in PubMed Open full text

Identifiers

PMID: 33378215
DOI: 10.1091/mbc.E20-07-0492
PMCID: PMC8098816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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