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Article

Distinct effects of tubulin isotype mutations on neurite growth in Caenorhabditis elegans.

Molecular biology of the cell - 15 Oct 2017

Zheng Chaogu, Diaz-Cuadros Margarete, Nguyen Ken C Q, Hall David H, Chalfie Martin

Abstract excerpt

Tubulins, the building block of microtubules (MTs), play a critical role in both supporting and regulating neurite growth. Eukaryotic genomes contain multiple tubulin isotypes, and their missense mutations cause a range of neurodevelopmental defects. Using the Caenorhabditis elegans touch receptor neurons, we analyzed the effects of 67 tubulin missense mutations on neurite growth. Three types of mutations...

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Identifiers

PMID: 28835377
DOI: 10.1091/mbc.E17-06-0424
PMCID: PMC5638583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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