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Article

Gamete binning: chromosome-level and haplotype-resolved genome assembly enabled by high-throughput single-cell sequencing of gamete genomes.

Genome biology - 29 Dec 2020

Campoy José A, Sun Hequan, Goel Manish, Jiao Wen-Biao, Folz-Donahue Kat, Wang Nan, Rubio Manuel, Liu Chang, Kukat Christian, Ruiz David, Huettel Bruno, Schneeberger Korbinian

Abstract excerpt

Generating chromosome-level, haplotype-resolved assemblies of heterozygous genomes remains challenging. To address this, we developed gamete binning, a method based on single-cell sequencing of haploid gametes enabling separation of the whole-genome sequencing reads into haplotype-specific reads sets. After assembling the reads of each haplotype, the contigs are scaffolded to chromosome level using a genetic map...

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Identifiers

PMID: 33372615
DOI: 10.1186/s13059-020-02235-5
PMCID: PMC7771071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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