Article
Complete assembly of parental haplotypes with trio binning
2018-02-26
Abstract excerpt
Reference genome projects have historically selected inbred individuals to minimize heterozygosity and simplify assembly. We challenge this dogma and present a new approach designed specifically for heterozygous genomes. “Trio binning” uses short reads from two parental genomes to partition long reads from an offspring into haplotype-specific sets prior to assembly. Each haplotype is then assembled independently,...
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Identifiers and source
- Literature Corpus work
- 1a9bd2f9-2a61-533f-8da3-1147f7f27edb
- DOI
- 10.1101/271486