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sgcocaller and comapr: personalised haplotype assembly and comparative crossover map analysis using single-gamete sequencing data.

Nucleic acids research - 11 Nov 2022

Lyu Ruqian, Tsui Vanessa, Crismani Wayne, Liu Ruijie, Shim Heejung, McCarthy Davis J

Abstract excerpt

Profiling gametes of an individual enables the construction of personalised haplotypes and meiotic crossover landscapes, now achievable at larger scale than ever through the availability of high-throughput single-cell sequencing technologies. However, high-throughput single-gamete data commonly have low depth of coverage per gamete, which challenges existing gamete-based haplotype phasing methods. In addition,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36107768
DOI: 10.1093/nar/gkac764
PMCID: PMC9723612

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