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Article

An ATM-Chk2-INCENP pathway activates the abscission checkpoint.

The Journal of cell biology - 1 Feb 2021

Petsalaki Eleni, Zachos George

Abstract excerpt

During cell division, in response to chromatin bridges, the chromosomal passenger complex (CPC) delays abscission to prevent chromosome breakage or tetraploidization. Here, we show that inhibition of ATM or Chk2 kinases impairs CPC localization to the midbody center, accelerates midbody resolution in normally segregating cells, and correlates with premature abscission and chromatin breakage in cytokinesis with...

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Identifiers

PMID: 33355621
DOI: 10.1083/jcb.202008029
PMCID: PMC7769160

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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