Article

A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability

2018-07-03

Abstract excerpt

Cytokinetic abscission facilitates the irreversible separation of daughter cells. This process requires the Endosomal Sorting Complexes Required for Transport (ESCRT) machinery and is tightly regulated by Charged Multivesicular body Protein 4C (CHMP4C), an ESCRT-III subunit that engages the abscission checkpoint (NoCut) in response to mitotic problems such as persisting chromatin bridges within the midbody. Import...

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Literature Corpus work: 8dfefede-6769-547e-b3fc-529091a8435a
DOI: 10.1101/361659

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