Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint.

Nature communications - 29 Apr 2016

Petsalaki Eleni, Zachos George

Abstract excerpt

When chromatin is trapped at the intercellular bridge, cells delay completion of cytokinesis (abscission) to prevent chromosome breakage. Here we show that inhibition of Cdc-like kinases (Clks) 1, 2 or 4 accelerates midbody resolution in normally segregating cells and correlates with premature abscission, chromatin breakage and generation of DNA damage in cytokinesis with trapped chromatin. Clk1, Clk2 and Clk4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aurora Kinase B
Share to Chromatin
Share to Chromosome Segregation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokinesis

Share to Endosomal Sorting Complexes Required for Transport

Share to Epithelial Cells

Share to Protein-Tyrosine Kinases

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 27126587
DOI: 10.1038/ncomms11451
PMCID: PMC4855533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint.PMID 27126587Read ↗

An ATM-Chk2-INCENP pathway activates the abscission checkpoint.Semantic proximity Read ↗

ESCRT-III Governs the Aurora B–Mediated Abscission Checkpoint Through CHMP4CSemantic proximity Read ↗

The NoCut pathway links completion of cytokinesis to spindle midzone function to prevent chromosome breakage.Semantic proximity Read ↗

PKCɛ switches Aurora B specificity to exit the abscission checkpoint.Semantic proximity Read ↗

ARF6 GTPase protects the post-mitotic midbody from 14-3-3-mediated disintegration.Semantic proximity Read ↗

Regulation of midzone microtubule dynamics and abscission in human cells by CAMSAP2 and Kif2aSemantic proximity Read ↗

A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instabilitySemantic proximity Read ↗

A Cul3-Based E3 Ligase Removes Aurora B from Mitotic Chromosomes, Regulating Mitotic Progression and Completion of Cytokinesis in Human CellsSemantic proximity Read ↗

Delayed abscission in animal cells – from development to defectsSemantic proximity Read ↗

PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.Semantic proximity Read ↗

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenanceSemantic proximity Read ↗

The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.