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Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

29 Jun 2010

Abstract excerpt

The ESCRT pathway helps mediate the final abscission step of cytokinesis in mammals and archaea. In mammals, two early acting proteins of the ESCRT pathway, ALIX and TSG101, are recruited to the midbody through direct interactions with the phosphoprotein CEP55. CEP55 resides at the centrosome through most of the cell cycle but then migrates to the midbody at the start of cytokinesis, suggesting that the ESCRT...

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PMID: 20616062
DOI: 10.1073/pnas.1005938107

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