Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ESCRT-III Governs the Aurora B–Mediated Abscission Checkpoint Through CHMP4C

16 Mar 2012

Abstract excerpt

The endosomal sorting complex required for transport (ESCRT) machinery plays an evolutionarily conserved role in cytokinetic abscission, the final step of cell division where daughter cells are physically separated. Here, we show that charged multivesicular body (MVB) protein 4C (CHMP4C), a human ESCRT-III subunit, is involved in abscission timing. This function correlated with its differential spatiotemporal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular transport and secretion
Share to Microtubule and mitosis dynamics
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22422861
DOI: 10.1126/science.1217180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ESCRT-III Governs the Aurora B–Mediated Abscission Checkpoint Through CHMP4CPMID 22422861Read ↗

The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis.Semantic proximity Read ↗

A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability.Semantic proximity Read ↗

A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instabilitySemantic proximity Read ↗

Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint.Semantic proximity Read ↗

PKCɛ switches Aurora B specificity to exit the abscission checkpoint.Semantic proximity Read ↗

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenanceSemantic proximity Read ↗

An ATM-Chk2-INCENP pathway activates the abscission checkpoint.Semantic proximity Read ↗

Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscissionSemantic proximity Read ↗

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.Semantic proximity Read ↗

Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14) in forming the stable intercellular bridges of germ cells.Semantic proximity Read ↗

The human AAA-ATPase VPS4A isoform and its co-factor VTA1 have a unique function in regulating mammalian cytokinesis abscissionSemantic proximity Read ↗

Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.