Article
The NoCut pathway links completion of cytokinesis to spindle midzone function to prevent chromosome breakage.
Cell - 7 Apr 2006
Norden Caren, Mendoza Manuel, Dobbelaere Jeroen, Kotwaliwale Chitra V, Biggins Sue, Barral Yves
Abstract excerpt
During anaphase, spindle elongation pulls sister chromatids apart until each pair is fully separated. In turn, cytokinesis cleaves the cell between the separated chromosomes. What ensures that cytokinesis proceeds only after that all chromosome arms are pulled out of the cleavage plane was unknown. Here, we show that a signaling pathway, which we call NoCut, delays the completion of cytokinesis in cells with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.