Article

Srs2/PARI DNA helicase mediates abscission inhibition in response to chromatin bridges in yeast and human cells

2024-11-13

Abstract excerpt

The coordination of chromosome segregation with cytokinesis is crucial for maintaining genomic stability. Chromatin bridges, arising from DNA replication stress or catenated chromosomes, can interfere with this process, leading to genomic instability if not properly managed. Here, we uncover that the budding yeast DNA helicase Srs2 and its human homolog PARI delay the timing of abscission events in the presence of...

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Literature Corpus work: 836a4940-13e3-554c-a545-9f49cdca9e91
DOI: 10.1101/2024.11.13.623343

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