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Article

PKCɛ switches Aurora B specificity to exit the abscission checkpoint.

Nature communications - 22 Dec 2016

Pike Tanya, Brownlow Nicola, Kjaer Svend, Carlton Jeremy, Parker Peter J

Abstract excerpt

The 'NoCut', or Aurora B abscission checkpoint can be activated if DNA is retained in the cleavage furrow after completion of anaphase. Checkpoint failure leads to incomplete abscission and a binucleate outcome. These phenotypes are also observed after loss of PKCɛ in transformed cell models. Here we show that PKCɛ directly modulates the Aurora B-dependent abscission checkpoint by phosphorylating Aurora B at...

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Identifiers

PMID: 28004745
DOI: 10.1038/ncomms13853
PMCID: PMC5192180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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