Article
TET2 haploinsufficiency alters reprogramming into induced pluripotent stem cells.
Stem cell research - 1 Apr 2020
Secardin Lise, Limia Cintia Elisabeth Gomez, di Stefano Antonio, Bonamino Martin Hernan, Saliba Joseph, Kataoka Keisuke, Rehen Stevens K, Raslova Hana, Marty Caroline, Ogawa Seishi, Vainchenker William, Monte-Mor Barbara da Costa Reis, Plo Isabelle
Abstract excerpt
The discovery of the Ten-Eleven Translocation (TET) protein family was initiated by the identification of the MLL partner TET1, and of mutations in the TET2 gene in hematological malignancies including myeloproliferative neoplasms (MPN). TET1, 2 and 3 proteins hydroxylate 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC) and further oxidize 5-hmC into 5-formylcytosine (5-fC) and 5-carboxylcytosine...
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