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Article

Connections between TET proteins and aberrant DNA modification in cancer.

Trends in genetics : TIG - 1 Oct 2014

Huang Yun, Rao Anjana

Abstract excerpt

DNA methylation has been linked to aberrant silencing of tumor suppressor genes in cancer, and an imbalance in DNA methylation-demethylation cycles is intimately implicated in the onset and progression of tumors. Ten-eleven translocation (TET) proteins are Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenases that successively oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine...

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Identifiers

PMID: 25132561
DOI: 10.1016/j.tig.2014.07.005
PMCID: PMC4337960

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OGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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