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Article

Autism-related deficits via dysregulated eIF4E-dependent translational control.

Nature - 17 Jan 2013

Gkogkas Christos G, Khoutorsky Arkady, Ran Israeli, Rampakakis Emmanouil, Nevarko Tatiana, Weatherill Daniel B, Vasuta Cristina, Yee Stephanie, Truitt Morgan, Dallaire Paul, Major François, Lasko Paul, Ruggero Davide, Nader Karim, Lacaille Jean-Claude, Sonenberg Nahum

Abstract excerpt

Hyperconnectivity of neuronal circuits due to increased synaptic protein synthesis is thought to cause autism spectrum disorders (ASDs). The mammalian target of rapamycin (mTOR) is strongly implicated in ASDs by means of upstream signalling; however, downstream regulatory mechanisms are ill-defined. Here we show that knockout of the eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2)-an eIF4E...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23172145
DOI: 10.1038/nature11628
PMCID: PMC4133997

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