Article

mTORC1 and mTORC2 regulate distinct aspects of glutamatergic synaptic transmission

2019-08-15

Abstract excerpt

Although mTOR signaling is known as a broad regulator of cell growth and proliferation, in neurons it regulates synaptic transmission, which is thought to be a major mechanism through which altered mTOR signaling leads to neurological disease. Although previous studies have delineated postsynaptic roles for mTOR, whether it regulates presynaptic function is largely unknown. Moreover, the mTOR kinase operates in tw...

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Literature Corpus work: 99275a3a-bbc7-53cc-aebb-176ecaee80e4
DOI: 10.1101/731554

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