Article
Neuronal Regulation of eIF2α Function in Health and Neurological Disorders.
Trends in molecular medicine - 1 Jun 2018
Moon Stephanie L, Sonenberg Nahum, Parker Roy
Abstract excerpt
A key site of translation control is the phosphorylation of the eukaryotic translation initiation factor 2α (eIF2α), which reduces the rate of GDP to GTP exchange by eIF2B, leading to altered translation. The extent of eIF2α phosphorylation within neurons can alter synaptic plasticity. Phosphorylation of eIF2α is triggered by four stress-responsive kinases, and as such eIF2α is often phosphorylated during...
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