Article
Rad51 determines pathway usage in post-replication repair.
Nature communications - 10 Jan 2026
Meyer Damon, Gore Steven K, Liu Jie, Ceballos Shannon J, Hung Shih-Hsun, Reginato Giordano, Cano-Linares Maria I, Maslowska Katarzyna H, Villafañez Florencia, Fasching Clare, Ede Christopher, Pagès Vincent, Prado Felix, Cejka Petr, Heyer Wolf-Dietrich
Abstract excerpt
Stalled replication forks are processed in post-replication repair by homologous recombination, fork regression, and translesion DNA synthesis. However, the regulation of pathway usage is not fully understood. Rad51 protein maintains genomic stability through its roles in recombination and in protecting stalled replication forks. We report isolation of mutations in Saccharomyces cerevisiae Rad51 that shift...
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