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Article

Fidelity consequences of the impaired interaction between DNA polymerase epsilon and the GINS complex.

DNA repair - 1 May 2015

Garbacz Marta, Araki Hiroyuki, Flis Krzysztof, Bebenek Anna, Zawada Anna E, Jonczyk Piotr, Makiela-Dzbenska Karolina, Fijalkowska Iwona J

Abstract excerpt

DNA polymerase epsilon interacts with the CMG (Cdc45-MCM-GINS) complex by Dpb2p, the non-catalytic subunit of DNA polymerase epsilon. It is postulated that CMG is responsible for targeting of Pol ɛ to the leading strand. We isolated a mutator dpb2-100 allele which encodes the mutant form of Dpb2p. We showed previously that Dpb2-100p has impaired interactions with Pol2p, the catalytic subunit of Pol ɛ. Here, we...

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Identifiers

PMID: 25758782
DOI: 10.1016/j.dnarep.2015.02.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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