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Article

Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.

PLoS genetics - 18 Nov 2010

Aksenova Anna, Volkov Kirill, Maceluch Jaroslaw, Pursell Zachary F, Rogozin Igor B, Kunkel Thomas A, Pavlov Youri I, Johansson Erik

Abstract excerpt

Yeast DNA polymerase ε (Pol ε) is a highly accurate and processive enzyme that participates in nuclear DNA replication of the leading strand template. In addition to a large subunit (Pol2) harboring the polymerase and proofreading exonuclease active sites, Pol ε also has one essential subunit (Dpb2) and two smaller, non-essential subunits (Dpb3 and Dpb4) whose functions are not fully understood. To probe the...

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Identifiers

PMID: 21124948
DOI: 10.1371/journal.pgen.1001209
PMCID: PMC2987839

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